An enzalutamide antiandrogen withdrawal syndrome
نویسندگان
چکیده
منابع مشابه
Molecular basis for the antiandrogen withdrawal syndrome.
In patients with prostate cancer who manifest disease progression during combined androgen blockade therapy, discontinuation of antiandrogen treatment might result in prostate-specific antigen decline, often associated with clinical improvement. The response called antiandrogen withdrawal syndrome is thus acknowledged as a general phenomenon. However, molecular mechanisms responsible for this s...
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Management of prostate cancer progression after failure of initial hormonal therapy is controversial. Recently, the activity of the simple discontinuation of antiandrogen therapy has been established by several groups, as well as the enhanced activity when combined with adrenal suppression (i.e., aminoglutethimide and hydrocortisone). Furthermore, suramin has generated considerable interest fol...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2014
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2014.145